Was looking into the 5HT (serotonin) receptor at work, and consequently came across information about LSD, which binds to the serotonin receptor. A particularly interesting site is that of Albert Hofmann, the scientist who first made LSD back in 1938. Initially the compound had been disregarded as it apparently had no interesting pharmacological effects. However, after resynthesising it in 1943, he made the following report:
Last Friday, April 16,1943, I was forced to interrupt my work in the laboratory in the middle of the afternoon and proceed home, being affected by a remarkable restlessness, combined with a slight dizziness. At home I lay down and sank into a not unpleasant intoxicated-like condition, characterized by an extremely stimulated imagination. In a dreamlike state, with eyes closed (I found the daylight to be unpleasantly glaring), I perceived an uninterrupted stream of fantastic pictures, extraordinary shapes with intense, kaleidoscopic play of colors. After some two hours this condition faded away.
He, and others in his department, went on to perform a series of “self-experiments” on LSD and its close chemical relations. Fascinating stuff! He also alludes to the effects LSD has on spiders, which can be seen here (OK, it’s a pdf; if you want jpegs just google for “lsd spiders”). Also on the Hoffman site, he quotes Werner A. Stoll’s paper “Lysergsaure-diathylamid, ein Phantastikum aus der Mutterkorngruppe” [Lysergic acid diethylamide, a phantasticum from the ergot group], describing the visions he experienced under the influence of LSD:
An evening sky of an unimaginable pale blue over the dark roofs of a Spanish city. I had a peculiar feeling of anticipation, was full of joy and decidedly ready for adventure. All at once the stars flared up, amassed, and turned to a dense rain of stars and sparks that streamed toward me. City and sky had disappeared.
Now I can see why the 70s were so tripped out!
posted by Simon (from Blogger) in
Science and have
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